# NIH Reporter #5R01HL167912-05

Novel Inhibitors for Temporal Modulation of T-Lymphocytes during Chronic Heart Failure

**Recipient:** Pennsylvania State University Hershey Medical Center

**Award Amount:** $578,432.00
**Ceiling:** $578,432.00

**Awarded:** September 08, 2026

**Identifier:** 5R01HL167912-05

NIH awarded a grant to Pennsylvania State University Hershey Medical Center to study novel inhibitors targeting T-lymphocytes for treating chronic heart failure, aiming to reduce cardiac remodeling and improve heart function.

### Description

This NIH grant project focuses on developing novel inhibitors to modulate T-lymphocytes during chronic heart failure to reduce left ventricular remodeling and heart failure progression. The study evaluates the therapeutic efficacy of a novel ERβ agonist, OSU-ERb-012, in selectively inhibiting pathogenic CD4+ T-cells and improving cardiac function post-myocardial infarction.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11395367)