Award
National Heart, Lung, and Blood Institute 1K08HL179451-01A1
Mechanisms Underlying the Immune Paradox in Sarcoidosis
Recipient
University of Illinois at Chicago
Award Amount
$174,560.00
Ceiling
$174,560.00
Awarded
June 03, 2026
Identifier
1K08HL179451-01A1
Research project funded by the National Heart Lung and Blood Institute to investigate immune cell dysfunction in sarcoidosis, focusing on mechanisms driving lymphopenia and T-cell exhaustion to develop targeted therapies.
Description
The project aims to define novel mechanisms involving CD4+ naïve T-cells and cDC1 that underlie peripheral lymphopenia and T-cell dysfunction in sarcoidosis. Understanding these mechanisms will facilitate the development of targeted therapies and interventions to mitigate disease progression.