Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR074105-09
Evolution of autoreactive GC and epitope spreading in lupus
Recipient
Boston Children's Hospital
Award Amount
$458,713.00
Ceiling
$458,713.00
Awarded
June 30, 2026
Identifier
5R01AR074105-09
NIH funded research project studying the mechanisms of epitope spreading and autoreactive B cells in lupus to understand disease progression.
Description
This project aims to characterize the developmental kinetics and dynamics of autoreactive B cell subsets involved in epitope spreading in systemic lupus erythematosus (SLE), using novel adoptive transfer models and spatial transcriptomics approaches.