Award
National Heart, Lung, and Blood Institute 11194947
The Role of c-ABL in Mediating TIE2 Signaling and Formation of Venous Malformation
Recipient
University of Cincinnati
Award Amount
$46,950.00
Ceiling
$46,950.00
Awarded
August 14, 2025
Identifier
11194947
This award funds research to understand the role of c-ABL in TIE2 signaling and venous malformation formation using a mouse model, aiming to explore therapeutic targeting of c-ABL for VM treatment.
Description
Venous malformation (VM) is a disease in which patients are affected by enlarged and abnormal veins that cause pain, disfigurement, and other severe complications. This study will use a novel mouse model of VM to investigate how TIE2, a protein that is often mutated in VM patients, and c-ABL, a protein that is involved in TIE2 signaling, play a role in formation of VM. In doing so, this project will increase our understanding of the mechanisms that drive VM formation and will investigate the therapeutic potential of targeting c-ABL to treat VM patients.