Award
NIH Reporter #5R01NS123120-05
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems
Recipient
Massachusetts Institute of Technology
Award Amount
$362,374.00
Ceiling
$362,374.00
Awarded
May 07, 2026
Identifier
5R01NS123120-05
Award to Massachusetts Institute of Technology by National Institute of Neurological Disorders and Stroke for developing a non-human primate model to design and test Closed-Loop Anesthesia Delivery systems, aiming to improve anesthesiology safety and efficacy.
Description
This project aims to develop a non-human primate model for the design and testing of Closed-Loop Anesthesia Delivery (CLAD) systems for anesthetics such as propofol and dexmedetomidine. The research will involve neurophysiological recordings (EEG, local field potentials, neural spiking activity) in non-human primates during anesthetic administration, combined with pharmacokinetic and pharmacodynamic modeling, control theory, and signal processing to develop real-time CLAD systems. The long-term goal is to establish a paradigm for the development and testing of CLAD systems, making them a standard for brain state monitoring and drug dosing in anesthesiology, thereby enhancing patient safety and reducing anesthesia-related morbidities.