NIH Reporter #5K01DA053985-04

A longitudinal analysis of methamphetamine use, social relationships, and cognitive function among people living with HIV

The award supports research analyzing the relationships between methamphetamine use, social relationships, and cognitive function in people living with HIV, aiming to inform interventions to maintain brain health.

Description

This research will generate a novel line of high-impact evidence regarding connections among methamphetamine use, social relationships, and cognitive functioning among people with HIV across the life course (ages 18-87) and will highlight pathways to develop interventions to maintain brain health for this population. The Principal Investigator will utilize innovative and rigorous statistical methods including time-varying effect modeling and cross-lagged structural equation modeling by leveraging the NIH’s previous and ongoing investments in HIV and methamphetamine research at the University of California, San Diego. An understanding of how social relationships mediate the impacts of HIV and methamphetamine use on cognitive function across the life span can inform future treatment responses and care interventions designed to reduce substance use and negative impacts on cognitive function among people with co-occurring HIV and substance use disorders.

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