# NIH Reporter #2R35GM142588-06

Biophysical mechanism and synthetic engineering of optically controlled Ca2+-powered supramolecular engines

**Recipient:** University of Colorado

**Award Amount:** $2,165,625.00
**Ceiling:** $2,165,625.00

**Awarded:** August 13, 2026

**Identifier:** 2R35GM142588-06

The project studies the mechanisms behind calcium-triggered contractions in centrin/Sfi1 protein assemblies and aims to build synthetic, AI-controlled myonemes for programmable force generation.

### Description

NIH-funded research investigating how calcium-responsive centrin/Sfi1 myonemes generate mechanical force and engineering synthetic myonemes with programmable, light-controlled actuation.

[View original record](https://reporter.nih.gov/search/47CiHD0bJ0u2LtDABS0zbg/project-details/11331470)