Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5F31HD114406-03
AAV gene therapy to restore fertility in mammalian Sertoli cell dysfunction models
Recipient
MAGEE-WOMEN'S RES INST AND FOUNDATION
Award Amount
$50,114.00
Ceiling
$50,114.00
Awarded
March 09, 2026
Identifier
5F31HD114406-03
This NIH-funded project focuses on developing AAV gene therapy to restore fertility by targeting Sertoli cell dysfunction in mammalian models, including mouse models and human testis organ culture techniques.
Description
The project involves testing the safety and feasibility of Sertoli cell gene therapy using AAV vectors. The project aims to develop a bench to bedside approach for testicular somatic cell gene therapy. It includes creating mouse models of human NOA and testing AAV-mediated Sertoli cell gene therapy. The project will utilize a human testis organ culture technique to identify Sertoli cell specific AAV serotypes.