Award
National Institute of Environmental Health Sciences 5R00ES033771-05
Investigating the Cellular Impact of 8-oxo-Guanine on DNA Replication and Genome Stability
Recipient
University of Kansas Medical Center, Kansas City, KS, United States
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
December 08, 2025
Identifier
5R00ES033771-05
The award supports research on how oxidative DNA damage, particularly 8-oxo-Guanine, affects DNA replication and genome stability, using innovative methods to induce and study these lesions, with relevance to cancer and aging.
Description
This project aims to elucidate the impact of oxidative DNA damage, specifically 8-oxo-Guanine, on DNA replication and genome stability, with implications for understanding cancer and aging. The study uses novel chemoptogenetic tools to specifically induce 8oxoG lesions in the human genome and investigates their effects on DNA replication fork integrity and cell fate.