Award
NIH Reporter #7R01AR086165-02
Mitochondrial DNA leakage promotes inflammation and intervertebral disc degeneration
Recipient
University of Toledo Health Sci Campus
Award Amount
$502,610.00
Ceiling
$502,610.00
Awarded
September 22, 2026
Identifier
7R01AR086165-02
The project studies the role of oxidatively damaged mitochondrial DNA in sterile inflammation and intervertebral disc degeneration, using cell, tissue, and mouse models to examine mtDNA escape and cGAS/STING pathway activation.
Description
Research project investigating how oxidative damage and leakage of mitochondrial DNA activates inflammation in intervertebral discs and contributes to disc degeneration, with the goal of identifying therapeutic targets.