Award
NIH Reporter #1RF1AG091479-01A1
Evaluation of the neuroimmune mechanisms influencing therapeutic targeting potential of the LH/CG receptor in the menopausal and AD brain
Recipient
University of Florida, Gainesville, FL, United States
Award Amount
$2,329,970.00
Ceiling
$2,329,970.00
Awarded
August 27, 2025
Identifier
1RF1AG091479-01A1
The award funds research on the neuroimmune mechanisms of the LH/CG receptor in the menopausal and Alzheimer's disease brain, focusing on its role in neuroinflammation and therapeutic potential.
Description
This project investigates the neuroimmune mechanisms of LH/CG receptor signaling in relation to menopause and Alzheimer’s disease, with potential implications for other neurological conditions involving neuroinflammation. The research aims to evaluate cell-specific roles of LHCGR signaling on CNS function, neuroplasticity, and inflammation; determine if stimulating this receptor inhibits peripheral infiltration and how age, reproductive status, and amyloidosis impact benefits; and assess how baseline levels of LH, receptor expression, and cellular localization influence therapy outcomes.