Award
National Institute of General Medical Sciences 2R15GM140372-02
THE ROLE OF eIF3 IN mRNA RECRUITMENT
Recipient
VASSAR COLLEGE
Award Amount
$396,297.00
Ceiling
$396,297.00
Awarded
September 19, 2024
Identifier
2R15GM140372-02
This NIH grant funds research to understand the mechanistic roles of eIF3 in mRNA recruitment during translation initiation and its implications in cancer development and progression.
Description
Translation initiation is the rate-limiting and most highly regulated phase of translation, and its misregulation causes human cancers. Altered expression of each of the subunits composing the multi-subunit eukaryotic initiation factor 3 (eIF3)—a key player in translation initiation and the regulation of translation—causes cancer development and progression, but a mechanism for this link has yet to be elucidated. Our work promises to shed new light on the functional roles of eIF3 and its individual subunits and thus provide a mechanistic framework for their participation in translation initiation, translational regulation, and the development and progression of human cancers.