Award
National Institute of Allergy and Infectious Diseases 1K08AI196234-01
A Transposon-based Gene Drive to Combat Antimicrobial Resistance
Recipient
Brigham and Women's Hospital
Award Amount
$171,046.00
Ceiling
$171,046.00
Awarded
April 01, 2026
Identifier
1K08AI196234-01
Development of a transposon-based gene drive to eliminate antimicrobial resistance genes in bacterial populations, focusing on E. coli ST131, to address the global threat of antimicrobial resistance.
Description
This project aims to develop a transposon-based gene drive to combat antimicrobial resistance by harnessing mobile genetic elements to eliminate resistance genes from bacterial populations, focusing on E. coli ST131 as a model pathogen. The research builds upon high-throughput genetic tools and aims to optimize gene drive transmission and efficacy.