Award
NIH Reporter #1R21NS147536-01A1
Roles of DNMT3a-Mediated Oligodendrogenesis in Post-Stroke Dementia
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$435,550.00
Ceiling
$435,550.00
Awarded
August 14, 2026
Identifier
1R21NS147536-01A1
The study aims to understand how DNMT3a influences oligodendrogenesis and white matter repair after stroke, using mouse models to identify gene regulation mechanisms, with the goal of developing therapies to improve recovery in stroke survivors.
Description
This project investigates the mechanisms of compensatory oligodendrogenesis in post-stroke conditions, focusing on the role of DNMT3a in regulating OPC function during recovery. The research aims to develop targeted therapeutic strategies to enhance white matter repair and improve quality of life in stroke survivors.