Award
National Institute of Allergy and Infectious Diseases 5R01AI165533-04
The role for ER associated degradation (ERAD) in T cell homeostasis and memory
Recipient
University of Michigan at Ann Arbor
Award Amount
$508,357.00
Ceiling
$508,357.00
Awarded
February 23, 2026
Identifier
5R01AI165533-04
This NIH grant supports research on the role of ER associated degradation in regulating CD8+ T cells, which are crucial for immunity against viral infections. The study aims to understand protein quality control mechanisms to enhance T cell responses for infectious diseases and vaccination.
Description
Research to identify how Sel1L/ERAD controls CD8+ T cell fate at steady-state and after infection, aiming to discover new therapeutic targets to modulate human T cell responses.