Award
National Cancer Institute 1R01CA296797-01A1
Decoding the Cullin-5 complex to engineer therapeutic T cells with durable effector function
Recipient
University of California, San Francisco
Award Amount
$680,598.00
Ceiling
$680,598.00
Awarded
August 14, 2025
Identifier
1R01CA296797-01A1
NIH grant awarded to University of California, San Francisco to study the Cullin-5 complex in T cells to enhance cancer immunotherapy durability and effectiveness.
Description
This project aims to understand and manipulate the Cullin-5 (Cul5) complex to improve T cell therapies for cancer, potentially leading to more durable and effective treatments. The research involves identifying Cul5 subunits driving T cell dysfunction, evaluating manipulation of Cul5 in preclinical T cell models, and assessing how Cul5 loss affects cytokine response and synergy with cytokine circuits.