Award
National Heart, Lung, and Blood Institute 5R01HL165840-04
PRE-DETERMINE: Advancing Sudden Arrhythmic Death Prediction in Coronary Artery Disease in the Absence of Severe Systolic Dysfunction
Recipient
Cedars-Sinai Medical Center
Award Amount
$1,491,021.00
Ceiling
$1,491,021.00
Awarded
March 19, 2026
Identifier
5R01HL165840-04
Award for research project to develop risk prediction models for sudden arrhythmic death in coronary artery disease patients using clinical and biomarker data, employing machine learning methods.
Description
The project aims to develop and validate multi-marker risk prediction models for sudden arrhythmic death (SAD) in patients with coronary heart disease (CHD) and LVEF >30-35%. The study involves analysis of clinical, ECG, imaging, biomarker, and genetic data. The project will utilize machine learning approaches and novel biomarker analyses. It is part of a multicenter cohort of 5761 CHD patients. The goal is to identify high-risk individuals for inclusion in primary prevention ICD trials and explore mechanistic pathways for SAD prevention.