Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1R01AR087085-01
Molecular Mechanism of Human Myogenesis
Recipient
University of Georgia, Athens, GA, United States
Award Amount
$614,390.00
Ceiling
$614,390.00
Awarded
May 01, 2026
Identifier
1R01AR087085-01
Research grant awarded to study the molecular mechanisms of human myogenesis focusing on CHAMP1 gene mutations and their role in muscle disease, aiming to develop therapeutic strategies.
Description
This project aims to elucidate CHAMP1’s role in muscle development and disease, identify molecular targets, and develop strategies to treat muscle symptoms. The research involves molecular and phenotypic analyses, leveraging mouse models, spatial transcriptomics, and structural modeling to understand how CHAMP1 mutations cause myopathy and to develop potential therapies.