Award
National Institute of Neurological Disorders and Stroke 5R01NS128031-05
Mechanisms of Thalamocortical Dysfunction and Social Deficits in FTD due to GRN Mutations
Recipient
Not specified
Award Amount
$404,304.00
Ceiling
$404,304.00
Awarded
June 23, 2026
Identifier
5R01NS128031-05
NIH-funded research project studying the mechanisms of frontotemporal dementia caused by GRN mutations, focusing on lysosomal activity and brain circuitry.
Description
This project aims to investigate the cellular and molecular mechanisms by which progranulin insufficiency causes frontotemporal dementia (FTD), focusing on lysosomal activity and thalamocortical circuitry. The award is funded by the NIH and involves multiple aims including testing in primary neurons and mouse models.