Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK141169-03
Dissecting heterogeneity in hematopoietic stem and progenitor cell ontogeny
Recipient
Albert Einstein College of Medicine
Award Amount
$520,649.00
Ceiling
$520,649.00
Awarded
May 25, 2026
Identifier
5R01DK141169-03
This NIH-funded project studies the heterogeneity and functional differences of hematopoietic stem and progenitor cells during development using zebrafish models to improve understanding of immune disorders and stem cell therapies.
Description
The project aims to understand the functional differences and heterogeneity of hematopoietic stem cells (HSCs) and HSC-independent progenitors during embryonic development using zebrafish models. It involves visualization, transcriptional characterization, lineage tracing, genetic screening, and functional assays to uncover the regulation and differentiation potentials of these cells within their native environment. The research is relevant to immune disorders and the production of stem cells for treatment.