Award
Massachusetts General Hospital 4DP2AG082342-02
The inactive X: discovering sex genes that influence female vulnerability to Alzheimer's disease
Recipient
Massachusetts General Hospital
Award Amount
$993,000.00
Ceiling
$993,000.00
Awarded
January 21, 2026
Identifier
4DP2AG082342-02
Research project awarded to Massachusetts General Hospital to study X-linked genes affecting female vulnerability to Alzheimer's disease using genomic and neuroimaging data.
Description
This project focuses on the role of X-linked genes that escape inactivation on the second X chromosome in women, exploring their impact on Alzheimer's disease vulnerability through genomic, transcriptomic, and epigenetic analyses, leveraging neuroimaging and sequencing data from large cohorts.