Award
NIH Reporter #1R01AI193146-01A1
Bioinformatics guided synthesis of novel antibiotics from previously inaccessible microbial dark matter
Recipient
Rockefeller University, New York, NY, United States
Award Amount
$798,670.00
Ceiling
$798,670.00
Awarded
May 27, 2026
Identifier
1R01AI193146-01A1
The award supports research to discover new antibiotics from microbial dark matter using advanced sequencing and bioinformatics techniques to address antibiotic resistance.
Description
This project aims to couple long read sequencing methods with bioinformatics to guide the synthesis of novel antibiotics encoded by microbial dark matter. The research will involve direct Nanopore metagenomic sequencing to access biosynthetic gene clusters and the use of synthetic bioinformatic natural products (synBNPs) to generate compounds with potential clinical candidates.