Award
National Institute of Allergy and Infectious Diseases 5P01AI177687-04
Multi-Omics Correlates of Broadly Neutralizing Antibody Efficacy
Recipient
Beth Israel Deaconess Medical Center, Boston, MA, United States
Award Amount
$276,640.00
Ceiling
$276,640.00
Awarded
April 27, 2026
Identifier
5P01AI177687-04
The award supports research to elucidate how broadly neutralizing antibodies control HIV-1 by targeting viral reservoirs and modulating immune responses, using multi-omics approaches in humans and nonhuman primates.
Description
This project aims to understand the mechanism underlying the efficacy of broadly neutralizing antibodies (bNAbs) in delaying viral rebound in HIV-1-infected humans and SHIV-infected nonhuman primates. It involves multi-omics analysis and interventional studies to define the impact of bNAb therapy on the viral reservoir and host immune responses, providing insights for HIV-1 cure strategies.