Award
National Institute of General Medical Sciences 5R01GM136960-06
The role of collisions in rescuing stalled ribosomes in bacteria
Recipient
Johns Hopkins University, Baltimore, MD, United States
Award Amount
$334,206.00
Ceiling
$334,206.00
Awarded
December 11, 2025
Identifier
5R01GM136960-06
This project aims to determine molecular mechanisms of ribosome quality control (RQC) in bacteria, focusing on how bacterial cells rescue stalled ribosomes, which is important for understanding antibiotic effects and bacterial protein synthesis.
Description
Many antibiotics inhibit protein synthesis in bacteria by interfering with the function of ribosomes. The proposed studies will increase our understanding of how bacterial cells sense that problems have occurred during protein synthesis and will reveal the mechanisms by which they resolve these problems.