Award
National Institute of General Medical Sciences 5R01GM152667-03
Mechanism and Significance of HMG Co-A Synthase 1 Degradation
Recipient
Sloan-Kettering Inst Can Research, New York, NY, United States
Award Amount
$366,810.00
Ceiling
$366,810.00
Awarded
April 02, 2026
Identifier
5R01GM152667-03
This award funds research on the regulation and degradation of HMGCS1 enzyme in the mevalonate pathway, exploring its role in cholesterol synthesis and cell proliferation, with implications for cancer and metabolic diseases.
Description
The research investigates the regulation of HMGCS1, the first enzyme in the mevalonate pathway, which is critical for cholesterol synthesis and other metabolites. The study focuses on how mTORC1 signaling influences HMGCS1 stability and degradation via the ubiquitin-proteasome system, and its role as a gatekeeper of pathway flux.