Award
NIH Reporter #1K22AI192774-01
Therapeutically Targeting Kinases in KSHV Disease
Recipient
University of Nebraska Medical Center, Omaha, NE
Award Amount
$160,352.00
Ceiling
$160,352.00
Awarded
August 11, 2026
Identifier
1K22AI192774-01
Research project funded by NIAID to study ERBB2 and ERBB3 kinases in KSHV replication and Kaposi’s sarcoma, aiming to develop targeted therapies.
Description
This project aims to elucidate the roles of ERBB2 and ERBB3 kinases in the replication of Kaposi’s sarcoma herpesvirus (KSHV) and their relevance in Kaposi’s sarcoma (KS). The research involves dissecting ERBB-dependent signaling pathways, applying targeted protein degradation technology, and evaluating therapeutic targets in endothelial models and KS patient biopsies.