Award

National Institute of Allergy and Infectious Diseases 7R01AI175831-04

Targeting host lipid metabolism to limit tissue damage in necrotizing fasciitis

Recipient

University of Southern California, Los Angeles, CA

Award Amount

$644,923.00

Ceiling

$644,923.00

Awarded

March 31, 2026

Identifier

7R01AI175831-04

This NIH grant supports research on how host lipid metabolism affects tissue damage in necrotizing fasciitis, aiming to identify therapeutic targets to limit damage from bacterial toxins.

Description

Necrotizing fasciitis (NF) is a bacterial infection characterized by extensive tissue destruction, requiring hospitalization, systemic antibiotics, and surgery. The project aims to understand how lipid metabolism influences tissue damage caused by CDC toxins and to explore lipid homeostasis as a potential therapeutic target.

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