Award
NIH Reporter #3R01AG058063-09S2
Harnessing Diverse Bioinformatic Approaches To Repurpose Drugs For Alzheimers Disease And Related Dementias
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$115,560.00
Ceiling
$115,560.00
Awarded
July 08, 2026
Identifier
3R01AG058063-09S2
This award funds a project aimed at repurposing FDA-approved drugs for Alzheimer's disease using bioinformatics and EHR data. It integrates systems pharmacology, chemical biology, and causal inference to identify therapeutic targets and drug candidates, with an emphasis on open data sharing.
Description
Repurposing existing FDA-approved drugs to accelerate clinical trials for Alzheimer's disease by leveraging bioinformatics, expression data, and electronic health records (EHR). The project involves systems pharmacology, chemical biology, and causal inference strategies to identify pathways, targets, and drug signals relevant to Alzheimer's disease progression. Data and software will be openly shared following FAIR standards to support further research and clinical trials.