Award
National Institute on Aging 5R01AG075837-03
Contribution of a novel OPN-producing CD11c+ microglial subset to AD
Recipient
Dana-Farber Cancer Institute, Boston, MA, United States
Award Amount
$505,974.00
Ceiling
$505,974.00
Awarded
January 07, 2026
Identifier
5R01AG075837-03
This award funds research on a novel microglial subset producing Osteopontin in Alzheimer's Disease, aiming to understand its role in disease progression and develop targeted therapies.
Description
The project investigates a microglial subset in Alzheimer’s Disease (AD) that produces Osteopontin (OPN) and drives disease pathology. It aims to validate findings in human brain tissues, explore therapeutic targeting of OPN, and understand microglial phenotypes to develop potential treatments.