Award
National Institute of Neurological Disorders and Stroke 5R21NS140497-02
Dystrophin as a novel regulator of the circadian clock in skeletal muscle and the brain
Recipient
University of Alabama at Birmingham, Birmingham, AL, United States
Award Amount
$187,316.00
Ceiling
$187,316.00
Awarded
December 05, 2025
Identifier
5R21NS140497-02
Research project funded by the National Institute of Neurological Disorders and Stroke to study the role of dystrophin in circadian regulation and muscular health in Duchenne muscular dystrophy using a mouse model.
Description
This project investigates the contribution of circadian rhythm disruption to Duchenne muscular dystrophy (DMD) disease pathology, focusing on the role of Dystrophin in skeletal muscle and the brain's suprachiasmatic nucleus (SCN). It utilizes a conditional dystrophin loss-of-function mouse model to evaluate its impact on circadian regulation and muscular health.