Award
National Institute on Aging 11181575
Testing sex as a moderator of health impacts of upward mobility on indicators for AD risk in young adulthood
Recipient
UNIVERSITY OF CALIFORNIA LOS ANGELES
Award Amount
$739,186.00
Ceiling
$739,186.00
Awarded
August 07, 2025
Identifier
11181575
The project studies the effects of adolescent upward mobility on cognitive health and Alzheimer's risk, focusing on sex differences, using a natural experiment from charter schools to analyze biological and cognitive outcomes.
Description
This project investigates how upward mobility during adolescence affects cognitive health and Alzheimer's disease (AD) risk, with a focus on sex differences. It uses a natural experiment from public charter high schools to compare groups with different mobility opportunities. The study aims to assess the impact of mobility on cognitive ability and resilience to AD, moderated by sex; explore links between mobility, inflammatory markers, and gut microbiome, considering sex and ApoE-ε4 status; and examine associations between health markers, brain structure/function, and cognitive outcomes.