Award
National Institute of Neurological Disorders and Stroke 5R01NS105680-08
Establishing the Function of TMEM184B in mTORC1 Regulation and Synaptic Maintenance
Recipient
University of Arizona
Award Amount
$398,827.00
Ceiling
$398,827.00
Awarded
May 19, 2026
Identifier
5R01NS105680-08
NIH grant awarded to University of Arizona to study TMEM184B's role in mTORC1 regulation and synaptic maintenance, focusing on neurological disease mechanisms.
Description
This NIH grant project aims to elucidate TMEM184B's role in neuronal signaling pathways, particularly its impact on mTORC1 activity, using primary cortical neuron cultures, Drosophila models, and molecular assays. The project addresses synaptic disruption linked to neurological diseases and seeks to evaluate TMEM184B's contribution to mTORC1 signaling, model human TMEM184B variants, and determine its molecular function.