Award
National Institute of Dental and Craniofacial Research 4R01DE029951-02
Targeting Endosomal Receptors for Treatment of Chronic Pain
Recipient
New York University, New York, NY
Award Amount
$795,324.00
Ceiling
$795,324.00
Awarded
July 31, 2024
Identifier
4R01DE029951-02
This NIH-funded project focuses on discovering novel pain mechanisms involving endosomal GPCRs and developing nanoparticle-based probes to validate therapeutic targets for chronic pain treatment.
Description
The project aims to discover mechanisms of eGPCR signaling in neurons, how eGPCRs regulate ion channels, and validate eGPCRs as therapeutic targets for chronic pain. It involves biophysical, imaging, electrophysiology, and nanoparticle approaches.