Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R01DK144476-01
Cellular Senescence and the AKI to CKD transition
Recipient
Washington University
Award Amount
$1,491,303.00
Ceiling
$1,491,303.00
Awarded
September 05, 2025
Identifier
1R01DK144476-01
This NIH-funded project investigates the role of cellular senescence in the progression from AKI to CKD, focusing on molecular mechanisms and potential therapies.
Description
The project aims to understand how cellular senescence drives the transition from acute kidney injury (AKI) to chronic kidney disease (CKD), focusing on the Foxm1-CCNF axis and potential therapeutic targets. It explores therapeutic interventions including senolytics and senomorphics to prevent CKD progression.