Award
National Institute of General Medical Sciences 5R01GM114564-09
Analysis of mRNP granule clearance, vacuolar RNA decay and TDP-43 turnover
Recipient
University of Arizona
Award Amount
$310,873.00
Ceiling
$310,873.00
Awarded
May 02, 2025
Identifier
5R01GM114564-09
NIH grant awarded to University of Arizona to study cellular clearance mechanisms of RNA and protein complexes, with implications for ALS and cancer therapies.
Description
This NIH grant project aims to understand the mechanisms of clearance of cytoplasmic RNA, protein and mRNA-protein granules, focusing on stress granules, P-bodies, and TDP-43 protein turnover. The research seeks to elucidate pathways involved in RNA and protein homeostasis relevant to diseases such as ALS and cancer, using genetic, biochemical, and cell biology assays.