Award
NIH Reporter #7R01GM140143-06
In-Vivo Monitoring of Therapeutic Drug Transport Across Biological Barriers
Recipient
University of North Carolina at Chapel Hill, NC
Award Amount
$301,315.00
Ceiling
$301,315.00
Awarded
February 02, 2026
Identifier
7R01GM140143-06
This award funds research to develop electrochemical aptamer-based sensors for monitoring drug transport across biological barriers in vivo, supporting improved drug development and dosing strategies.
Description
The project aims to measure molecular transport across biological barriers such as the blood-brain and blood-cerebrospinal fluid barriers in vivo. It will deploy electrochemical, aptamer-based sensors to monitor the transport parameters of seven therapeutics across three biological barriers, including blood-liver, blood-prostate, and blood-brain barriers. The goal is to generate permeability data to guide drug development and optimize dosing regimens.