Award
National Heart, Lung, and Blood Institute 5R01HL175155-02
Defining targetable vulnerabilities in UBA1-mutated VEXAS HSCs for clonal eradication
Recipient
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
Award Amount
$747,490.00
Ceiling
$747,490.00
Awarded
February 26, 2026
Identifier
5R01HL175155-02
NIH grant awarded to study UBA1-mutated VEXAS syndrome using advanced single-cell and spatial analysis techniques to identify therapeutic targets.
Description
The project focuses on exploring the mechanisms of VEXAS syndrome caused by somatic mutations in the UBA1 gene. The research involves single-cell and spatial analysis, genotype-aware single-cell multi-omics, and spatial transcriptomics. The project aims to identify key factors for targeted therapies and validate potential targets using in vitro and in vivo models.