Award
National Institute of General Medical Sciences 5R01GM108618-11
Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure Renewal
Recipient
University of Pittsburgh at Pittsburgh, Department of Pediatrics
Award Amount
$398,178.00
Ceiling
$398,178.00
Awarded
July 01, 2026
Identifier
5R01GM108618-11
NIH grant project focused on pediatric sepsis-induced organ failure, using machine learning and metabolomics to develop personalized therapies targeting immune-metabolic dysregulation.
Description
This project aims to understand and treat pediatric sepsis-induced organ failure by investigating inflammatory phenotypes, genetic variants, and viral infections such as Epstein-Barr Virus. The study will measure plasma metabolomics, analyze gene variants, and examine viral reactivation to develop personalized therapies targeting immune-metabolic dysregulation.