Award
NIH Reporter #5R01DK131476-05
Impact of metabolic programing of T cells from the GI tract and related tissues on HIV reservoir seeding, maintenance and reactivation
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$775,381.00
Ceiling
$775,381.00
Awarded
August 21, 2026
Identifier
5R01DK131476-05
Research project studying the influence of metabolic programming of gut T cells on HIV reservoir dynamics, assessing dietary impacts and potential therapeutic interventions to control HIV persistence.
Description
This project investigates how metabolic programming of T cells in the gastrointestinal tract and related tissues affects HIV reservoir seeding, maintenance, and reactivation. The study explores the impact of a Western diet on SIV reservoir formation and maintenance in rhesus macaques, focusing on gut T cells and related lymphoid tissues, and aims to identify new strategies to curb the HIV reservoir and control residual inflammation.