Award
National Cancer Institute 5R01CA297829-02
Growth suppressive and oncogenic transcriptional programs controlled by the androgen receptor in prostate cancer
Recipient
WEILL MEDICAL COLL OF CORNELL UNIV
Award Amount
$564,543.00
Ceiling
$564,543.00
Awarded
February 27, 2026
Identifier
5R01CA297829-02
This NIH-funded project studies the androgen receptor's dual role in prostate cancer, aiming to reactivate its growth-suppressive functions to inhibit cancer progression and identify new therapeutic targets.
Description
The project investigates the role of the androgen receptor (AR) in prostate cancer, focusing on how AR controls gene expression that suppresses growth in normal prostate tissue but promotes cancer in prostate cells. It aims to define the factors mediating the switch from growth suppression to oncogenic activity, and explore reactivating the normal AR programs in advanced prostate cancers to halt progression. The study will evaluate innovative strategies, identify new therapeutic targets, and establish a new paradigm for cancers dependent on lineage-specific, multifunctional transcription factors.