Award
National Institute of General Medical Sciences 5R35GM128855-08
Spindle Assembly Checkpoint Silencing
Recipient
University of North Carolina Chapel Hill, Department of Pharmacology
Award Amount
$454,118.00
Ceiling
$454,118.00
Awarded
July 25, 2025
Identifier
5R35GM128855-08
Research project funded by NIGMS to study cell cycle regulation mechanisms, focusing on spindle assembly checkpoint and protein degradation control, relevant to cancer and developmental biology.
Description
The project focuses on understanding the regulation of the cell cycle, specifically the spindle assembly checkpoint (SAC) and the anaphase-promoting complex/cyclosome (APC/C). The research aims to elucidate how conformational changes and molecular interactions control protein degradation and gene expression during mitosis and G1 phase, with implications for developmental biology and cancer.