Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK138940-03
PET Imaging of Renal Fibrosis
Recipient
Massachusetts General Hospital
Award Amount
$720,172.00
Ceiling
$720,172.00
Awarded
June 10, 2026
Identifier
5R01DK138940-03
A federal NIH grant awarded to Massachusetts General Hospital to develop a novel PET imaging probe for noninvasive detection of renal fibrosis, facilitating early diagnosis and treatment of kidney disease.
Description
This project aims to develop a noninvasive PET imaging method to detect renal fibrosis using allysine-targeted probes. The project includes developing an optimized PET probe, validating it in animal models and human biopsy samples, and conducting studies such as radiation dosimetry and toxicology to enable future human clinical trials.