Award
National Institute of Diabetes and Digestive and Kidney Diseases 1F31DK148101-01
The Impact of Delta Cell Gap Junction Disruption on Hormone Secretion and Glucose Homeostasis
Recipient
University of Colorado Denver, Aurora, CO
Award Amount
$41,618.00
Ceiling
$41,618.00
Awarded
May 20, 2026
Identifier
1F31DK148101-01
Research project funded by NIDDK to study how disruption of delta cell gap junctions affects hormone secretion and glucose regulation, potentially identifying new therapeutic targets for Type 2 Diabetes.
Description
This project aims to investigate the role of δ-cell Cx36 gap junctions in glucose regulation and hormone secretion, with potential implications for therapeutic targets in Type 2 Diabetes (T2D). The study will use a δ-cell specific Cx36 knockout mouse model to evaluate changes in δ-cell activity, hormone secretion, and glucose homeostasis, exploring the physiological significance of β-δ cell gap junctions and their disruption in diabetes.