Award
National Institute of Neurological Disorders and Stroke 5R21NS139481-02
Mechanisms that support Raphespinal tract plasticity and regeneration after spinal cord injury
Recipient
Yale University
Award Amount
$192,962.00
Ceiling
$192,962.00
Awarded
May 14, 2026
Identifier
5R21NS139481-02
Research project funded by the National Institute of Neurological Disorders and Stroke to study the plasticity and regeneration of the raphespinal tract after spinal cord injury, aiming to understand molecular mechanisms supporting rehabilitation-induced functional recovery.
Description
This project aims to elucidate the molecular and anatomical mechanisms underlying spinal cord injury recovery, with a focus on the plasticity of the raphespinal tract. The project focuses on the plasticity and regeneration of the raphespinal tract (RpST) after spinal cord injury (SCI), using anatomy, spatial transcriptomics, and intersectional in vivo chemogenetics to define the capacity and necessity of intact and lesioned supraspinal RpST terminals to support rehab-induced functional recovery.