Award
National Institute of Allergy and Infectious Diseases 2R01AI112949-10
Mechanism of colonization resistance
Recipient
University of California at Davis
Award Amount
$652,995.00
Ceiling
$652,995.00
Awarded
May 07, 2026
Identifier
2R01AI112949-10
This NIH grant funds research on how the probiotic E. coli Nissle 1917 protects against Salmonella infection by colonizing intestinal niches and competing for nutrients.
Description
Our gut microbiota protects us from infection through colonization resistance. This project investigates how E. coli Nissle 1917, a probiotic strain, confers protection against Salmonella infection by migrating into specific intestinal niches and competing for simple sugars, thereby preventing pathogen growth.