Award
National Institute of Mental Health 1R21MH132078-01A1
Heterogeneous microglia activation mediates stress-induced changes in neural circuitry.
Recipient
University of Texas Health Science Center, San Antonio, TX
Award Amount
$410,300.00
Ceiling
$410,300.00
Awarded
September 08, 2023
Identifier
1R21MH132078-01A1
This award funds research to understand how chronic stress activates microglia in the brain's prefrontal cortex, which may lead to new treatments for stress-related brain disorders.
Description
The project aims to determine how chronic stress causes heterogeneous activation of microglia in the medial prefrontal cortex, focusing on layer-specific signaling pathways and complement activation. It involves characterizing transcriptomes and generating a novel complement C3 conditional deletion/reporter/rescue mouse line to examine their involvement in the stress response, potentially leading to new microglia-based therapeutics.