Award
National Institute of Neurological Disorders and Stroke 5R01NS123431-05
Determining the mechanism of alpha-synuclein dependent innate immune responses in the brain
Recipient
UT SOUTHWESTERN MEDICAL CENTER
Award Amount
$300,395.00
Ceiling
$300,395.00
Awarded
April 02, 2026
Identifier
5R01NS123431-05
NIH awarded a grant to UT Southwestern Medical Center to study neuron-specific mechanisms regulating innate immune responses in the brain, focusing on alpha-synuclein's role in interferon signaling and Parkinson's Disease.
Description
This NIH grant project focuses on innate immune responses in the brain related to Parkinson’s Disease, specifically investigating alpha-synuclein mechanisms. The project aims to define interactions between alpha-synuclein, interferon signaling, and vesicle transport in neurons, and to evaluate the role of alpha-synuclein in immune responses in the brain.