Award
NIH Reporter #1R21EB036789-01A1
Establishing a stable production cell line for recombinant AAV through synthetic dynamic regulation and reducing regulatory and metabolic limitations
Recipient
University of Delaware, Newark, DE, United States
Award Amount
$436,658.00
Ceiling
$436,658.00
Awarded
August 07, 2025
Identifier
1R21EB036789-01A1
This NIH-funded project focuses on developing a stable producer cell line for recombinant AAV to improve gene therapy manufacturing efficiency and reduce costs by using synthetic dynamic regulation and optimized gene circuit design.
Description
The project aims to establish a stable cell line for recombinant AAV production by implementing synthetic dynamic regulation and reducing regulatory and metabolic limitations. It involves innovative gene expression control, cell line engineering, and mechanistic modeling to improve manufacturing efficiency and reduce costs.