# NIH Reporter #5R01DA054526-05

Modeling HIV Microglia-Associated Infection and Inflammation in a Chimeric Mouse Brain

**Recipient:** Icahn School of Medicine at Mount Sinai

**Award Amount:** $749,597.00
**Ceiling:** $749,597.00

**Awarded:** June 23, 2025

**Identifier:** 5R01DA054526-05

NIH-funded research investigating HIV latency, infection, and neuroinflammation in human microglia within a chimeric mouse brain, and evaluating therapies that may affect infection and inflammation.

### Description

The project studies HIV infection and persistence in human microglia residing in a mouse brain, including microglial inflammation and effects of antiretroviral and cannabinoid receptor 2 agonist treatments.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11094711)