Award
National Institute of Mental Health 5R01MH134893-03
Mitochondrial influences on blood brain barrier function and neuropsychiatric illness
Recipient
University of Pennsylvania, Philadelphia, PA
Award Amount
$678,683.00
Ceiling
$678,683.00
Awarded
December 02, 2025
Identifier
5R01MH134893-03
This award funds research on how mitochondrial energetics affect blood brain barrier function and neuropsychiatric disorders, particularly in 22q11.2 deletion syndrome. The study aims to understand BBB dysfunction mechanisms and explore therapeutic targets to improve brain health.
Description
Study of the synergistic influences of structural and energetic compromise on blood brain barrier (BBB) function, focusing on mitochondrial energetics in 22q11.2 deletion syndrome (22qDS) and its impact on neuropsychiatric illness. The project investigates mitochondrial compromise in BBB cells and potential therapeutic interventions to improve BBB function.